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Plant-Derived Exosomal MicroRNAs Shape the Gut Microbiota 期刊论文 WOS高被引论文

编号：

205664917DEF2F07BC6EEE8BBC3344CA
作者：

Teng, Yun#*^[2]Ren, Yi(任毅)#^[3]Sayed, Mohammed^[4];Hu, Xin^[5];Lei, Chao^[2];Kumar, Anil^[2];Hutchins, Elizabeth^[6];Mu, Jingyao^[2];Deng, Zhongbin^[2]Luo, Chao(罗超)^[2]Sundaram, Kumaran^[2];Sriwastva, Mukesh K.^[2];Zhang, Lifeng^[2];Hsieh, Michael^[4];Reiman, Rebecca^[4];Haribabu, Bodduluri^[2]Yan, Jun^[2]Jala, Venkatakrishna Rao^[2]Miller, Donald M.^[2]Van KeurenJensen, Kendall^[4]Merchant, Michael L.^[7,8]McClain, Craig J.^[1,9]Park, Juw Won^[4,10];Egilmez, Nejat K.^[2]Zhang, HuangGe*^[1,2]
语种：

英文
期刊：

CELL HOST & MICROBE ISSN：1931-3128 2018 年 24 卷 5 期 (637 - +) ; NOV 14
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摘要：

The gut microbiota can be altered by dietary interventions to prevent and treat various diseases. However, the mechanisms by which food products modulate commensals remain largely unknown. We demonstrate that plant-derived exosome-like nanoparticles (ELNs) are taken up by the gut microbiota and contain RNAs that alter microbiome composition and host physiology. Ginger ELNs (GELNs) are preferentially taken up by Lactobacillaceae in a GELN lipid-dependent manner and contain microRNAs that target various genes in Lactobacillus rhamnosus (LGG). Among these, GELN mdo-miR7267-3p-mediated targeting of the LGG monooxygenase ycnE yields increased indole-3-carboxaldehyde (I3A). GELN-RNAs or I3A, a ligand for aryl hydrocarbon receptor, are sufficient to induce production of IL-22, which is linked to barrier function improvement. These functions of GELN-RNAs can ameliorate mouse colitis via IL-22-dependent mechanisms. These findings reveal how plant products and their effects on the microbiome may be used to target specific host processes to alleviate disease.
推荐引用方式
GB/T 7714：

Teng Yun,Ren Yi,Sayed Mohammed, et al. Plant-Derived Exosomal MicroRNAs Shape the Gut Microbiota [J].CELL HOST & MICROBE,2018,24(5):637-+.
APA：

Teng Yun,Ren Yi,Sayed Mohammed,Hu Xin,&Zhang Huang-Ge.(2018).Plant-Derived Exosomal MicroRNAs Shape the Gut Microbiota .CELL HOST & MICROBE,24(5):637-+.
MLA：

Teng Yun, et al. "Plant-Derived Exosomal MicroRNAs Shape the Gut Microbiota" .CELL HOST & MICROBE 24,5(2018):637-+.
入库时间：

11/1/2023 6:15:17 PM
更新时间：

11/1/2023 6:15:17 PM
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